› 3gop

X-ray diffraction
2.8Å resolution

Crystal structure of the EGF receptor juxtamembrane and kinase domains

Released:
DOI: 10.2210/pdb3gop/pdb
PDB entry 3gop coloured by chain, front view.
PDB entry 3gop coloured by chain, side view.
PDB entry 3gop coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The juxtamembrane region of the EGF receptor functions as an activation domain.
Red Brewer M, Choi SH, Alvarado D, Moravcevic K, Pozzi A, Lemmon MA, Carpenter G
Mol Cell 34 641-51 (2009)
PMID: 19560417

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132671 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epidermal growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 361 amino acids
Theoretical weight: 41.67 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P00533 (Residues: 669-1022; Coverage: 30%)
Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P43212
Unit cell:
a: 62.073Å b: 62.073Å c: 177.158Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.208 0.259
Expression system: Spodoptera frugiperda

Quick links

Citations

48 review citations

Cell signaling by receptor tyrosine kinases.
Lemmon et al. (2010)
47 more

36 mentions without citation

Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.
Jura et al. (2011)
35 more