› 3gro

X-ray diffraction
2.53Å resolution

Human palmitoyl-protein thioesterase 1

Released:
DOI: 10.2210/pdb3gro/pdb
PDB entry 3gro coloured by chain, front view.
PDB entry 3gro coloured by chain, side view.
PDB entry 3gro coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Dobrovetsky E, Seitova A, Tong Y, Tempel W, Dong A, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Bochkarev A, Cossar D, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
Palmitoyl-[protein] + H(2)O = palmitate + [protein]
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156271 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Palmitoyl-protein thioesterase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 298 amino acids
Theoretical weight: 34.15 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P50897 (Residues: 22-306; Coverage: 100%)
Gene names: CLN1, PPT, PPT1
Sequence domains: Palmitoyl protein thioesterase
Structure domains: alpha/beta hydrolase

Ligands and Environments

1 bound ligand:
Ligand UNX 4 x UNX
1 modified residue:
Ligand MSE 18 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 53.71Å b: 90.642Å c: 129.165Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.2 0.238
Expression system: Spodoptera frugiperda

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