› 3gxb

X-ray diffraction
1.9Å resolution

Crystal structure of VWF A2 domain

Released:
DOI: 10.2210/pdb3gxb/pdb
PDB entry 3gxb coloured by chain, front view.
PDB entry 3gxb coloured by chain, side view.
PDB entry 3gxb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor.
Zhang Q, Zhou YF, Zhang CZ, Zhang X, Lu C, Springer TA
Proc Natl Acad Sci U S A 106 9226-31 (2009)
PMID: 19470641

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137563 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
von Willebrand factor Chains: A, B
Molecule details ›
Chains: A, B
Length: 184 amino acids
Theoretical weight: 20.82 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04275 (Residues: 1495-1671; Coverage: 6%)
Gene names: F8VWF, VWF
Sequence domains: von Willebrand factor type A domain
Structure domains: von Willebrand factor, type A domain

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand NAG 2 x NAG
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P21
Unit cell:
a: 55.11Å b: 60.81Å c: 56.35Å
α: 90° β: 99.09° γ: 90°
R-values:
R R work R free
0.185 0.183 0.224
Expression system: Not provided

Quick links

Citations

24 review citations

von Willebrand factor, Jedi knight of the bloodstream.
Springer TA. (2014)
23 more

32 mentions without citation

Von Willebrand factor: A key glycoprotein involved in thrombo-inflammatory complications of COVID-19.
Choudhary et al. (2021)
31 more