› 3h30

X-ray diffraction
1.56Å resolution

Crystal structure of the catalytic subunit of human protein kinase CK2 with 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole

Released:
DOI: 10.2210/pdb3h30/pdb
PDB entry 3h30 coloured by chain, front view.
PDB entry 3h30 coloured by chain, side view.
PDB entry 3h30 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The CK2 alpha/CK2 beta interface of human protein kinase CK2 harbors a binding pocket for small molecules.
Raaf J, Brunstein E, Issinger OG, Niefind K
Chem Biol 15 111-7 (2008)
PMID: 18291315

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-159383 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase II subunit alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 334 amino acids
Theoretical weight: 40.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68400 (Residues: 1-334; Coverage: 85%)
Gene names: CK2A1, CSNK2A1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand RFZ 3 x RFZ
Ligand CL 32 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X12
Spacegroup: P43
Unit cell:
a: 71.506Å b: 71.506Å c: 125.789Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.157 0.156 0.198
Expression system: Escherichia coli

Quick links

Citations

9 review citations

Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases.
Perez et al. (2011)
8 more

11 mentions without citation

Benzimidazole and its derivatives as cancer therapeutics: The potential role from traditional to precision medicine.
Lee et al. (2023)
10 more