› 3h8q

X-ray diffraction
2.21Å resolution

Crystal structure of glutaredoxin domain of human thioredoxin reductase 3

Released:
DOI: 10.2210/pdb3h8q/pdb
PDB entry 3h8q coloured by chain, front view.
PDB entry 3h8q coloured by chain, side view.
PDB entry 3h8q coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Chaikuad A, Johansson C, Ugochukwu E, Roos AK, von Delft F, Pilka E, Yue W, Arrowsmith CH, Edwards AM, Weigelt J, Bountra C, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183215 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thioredoxin reductase 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 114 amino acids
Theoretical weight: 13.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86VQ6 (Residues: 51-156; Coverage: 17%)
Gene names: TGR, TRXR3, TXNRD3
Sequence domains: Glutaredoxin
Structure domains: Glutaredoxin

Ligands and Environments

2 bound ligands:
Ligand SO4 3 x SO4
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P61
Unit cell:
a: 71.13Å b: 71.13Å c: 72.291Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.191 0.189 0.233
Expression system: Escherichia coli

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