› 3ha6

X-ray diffraction
2.36Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero tetramer
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127236 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Aurora kinase A Chain: A
Molecule details ›
Chain: A
Length: 268 amino acids
Theoretical weight: 31.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14965 (Residues: 125-391; Coverage: 66%)
Gene names: AIK, AIRK1, ARK1, AURA, AURKA, AYK1, BTAK, IAK1, STK15, STK6
Sequence domains: Protein kinase domain
Structure domains:
Targeting protein for Xklp2 Chain: B
Molecule details ›
Chain: B
Length: 44 amino acids
Theoretical weight: 4.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9ULW0 (Residues: 1-43; Coverage: 6%)
Gene names: C20orf1, C20orf2, DIL2, HCA519, TPX2
Sequence domains: Aurora-A binding

Ligands and Environments

1 bound ligand:
Ligand 2JZ 1 x 2JZ
1 modified residue:
Ligand TPO 2 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P3121
Unit cell:
a: 86.464Å b: 86.464Å c: 143.345Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.225 0.224 0.252
Expression system: Escherichia coli

Quick links

Citations

64 review citations

Small-molecule discovery from DNA-encoded chemical libraries.
Kleiner et al. (2011)
63 more

5 mentions without citation

Aurora A kinase (AURKA) in normal and pathological cell division.
Nikonova et al. (2013)
4 more