› 3hag

X-ray diffraction
3.5Å resolution

Crystal structure of the Hepatitis E Virus-like Particle

Released:
DOI: 10.2210/pdb3hag/pdb
PDB entry 3hag coloured by chain, front view.
PDB entry 3hag coloured by chain, side view.
PDB entry 3hag coloured by chain, top view.
Source organism: Orthohepevirus A
Primary publication:
Structure of the hepatitis E virus-like particle suggests mechanisms for virus assembly and receptor binding.
Guu TS, Liu Z, Ye Q, Mata DA, Li K, Yin C, Zhang J, Tao YJ
Proc Natl Acad Sci U S A 106 12992-7 (2009)
PMID: 19622744

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo 60-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-191563 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Secreted protein ORF2 Chain: A
Molecule details ›
Chain: A
Length: 504 amino acids
Theoretical weight: 54.45 KDa
Source organism: Orthohepevirus A
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9IVZ8 (Residues: 110-606; Coverage: 78%)
Gene name: ORF2
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P63
Unit cell:
a: 241.092Å b: 241.092Å c: 519.861Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.277 0.277 0.286
Expression system: Spodoptera frugiperda

Quick links

Citations

47 review citations

Hepatitis E.
Kamar et al. (2012)
46 more

11 mentions without citation

The development of a recombinant hepatitis E vaccine HEV 239.
Li et al. (2015)
10 more