› 3hfh

X-ray diffraction
2.7Å resolution

Crystal structure of tandem FF domains

Released:
DOI: 10.2210/pdb3hfh/pdb
PDB entry 3hfh coloured by chain, front view.
PDB entry 3hfh coloured by chain, side view.
PDB entry 3hfh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the three tandem FF domains of the transcription elongation regulator CA150.
Lu M, Yang J, Ren Z, Sabui S, Espejo A, Bedford MT, Jacobson RH, Jeruzalmi D, McMurray JS, Chen X
J. Mol. Biol. 393 397-408 (2009)
PMID: 19660470

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127124 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcription elongation regulator 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 190 amino acids
Theoretical weight: 23.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14776 (Residues: 661-845; Coverage: 17%)
Gene names: CA150, TAF2S, TCERG1
Sequence domains: FF domain

Ligands and Environments

No bound ligands
2 modified residues:
Ligand MSE 14 x MSE
Ligand MLY 60 x MLY

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P622
Unit cell:
a: 141.3Å b: 141.3Å c: 155.42Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.235 0.23 0.283
Expression system: Escherichia coli

Quick links

Citations

7 citation in other articles

A unified mechanism for intron and exon definition and back-splicing.
Li et al. (2019)
6 more

4 mentions without citation

Protein side-chain resonance assignment and NOE assignment using RDC-defined backbones without TOCSY data.
Zeng et al. (2011)
3 more