› 3hhc

X-ray diffraction
2.8Å resolution

Interferon-lambda is functionally an interferon but structurally related to the IL-10 family

Released:
DOI: 10.2210/pdb3hhc/pdb
PDB entry 3hhc coloured by chain, front view.
PDB entry 3hhc coloured by chain, side view.
PDB entry 3hhc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Interferon-lambda is functionally an interferon but structurally related to the interleukin-10 family.
Gad HH, Dellgren C, Hamming OJ, Vends S, Paludan SR, Hartmann R
J Biol Chem 284 20869-75 (2009)
PMID: 19457860

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184969 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon lambda-3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 196 amino acids
Theoretical weight: 21.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IZI9 (Residues: 1-196; Coverage: 100%)
Gene names: IFNL3, IL28B, IL28C, ZCYTO22
Sequence domains: Interleukin-28A
Structure domains: Interferon lambda

Ligands and Environments

1 bound ligand:
Ligand IOD 35 x IOD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X12
Spacegroup: P3121
Unit cell:
a: 91.118Å b: 91.118Å c: 150.209Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.265 0.261 0.314
Expression system: Escherichia coli

Quick links

Citations

62 review citations

Regulation and functions of the IL-10 family of cytokines in inflammation and disease.
Ouyang et al. (2011)
61 more

12 mentions without citation

Structural analysis of cytokines comprising the IL-10 family.
Zdanov A. (2010)
11 more