› 3hig

X-ray diffraction
2.09Å resolution

Crystal structure of human diamine oxidase in complex with the inhibitor berenil

Released:
DOI: 10.2210/pdb3hig/pdb
PDB entry 3hig coloured by chain, front view.
PDB entry 3hig coloured by chain, side view.
PDB entry 3hig coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and inhibition of human diamine oxidase.
McGrath AP, Hilmer KM, Collyer CA, Shepard EM, Elmore BO, Brown DE, Dooley DM, Guss JM
Biochemistry 48 9810-22 (2009)
PMID: 19764817

Function and Biology Details

Reaction catalysed: 
Histamine + H(2)O + O(2) = (imidazol-4-yl)acetaldehyde + NH(3) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148733 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Diamine oxidase [copper-containing] Chains: A, B
Molecule details ›
Chains: A, B
Length: 731 amino acids
Theoretical weight: 83.46 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P19801 (Residues: 21-751; Coverage: 100%)
Gene names: ABP, ABP1, AOC1, DAO
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
4 bound ligands:
Ligand CU 2 x CU
Ligand CA 4 x CA
Ligand GOL 1 x GOL
Ligand BRN 2 x BRN
1 modified residue:
Ligand TPQ 2 x TPQ

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P212121
Unit cell:
a: 92.662Å b: 94.884Å c: 196.411Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.171 0.168 0.21
Expression system: Drosophila melanogaster

Quick links

Citations

17 review citations

Human copper-dependent amine oxidases.
Finney et al. (2014)
16 more

4 mentions without citation

Copper active sites in biology.
Solomon et al. (2014)
3 more