› 3hil

X-ray diffraction
2Å resolution

SAM Domain of Human Ephrin Type-A Receptor 1 (EphA1)

Released:
DOI: 10.2210/pdb3hil/pdb
PDB entry 3hil coloured by chain, front view.
PDB entry 3hil coloured by chain, side view.
PDB entry 3hil coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Walker JR, Yermekbayeva L, Butler-Cole C, Weigelt J, Bountra C, Arrowsmith CH, Edwards AM, Bochkarev A, Dhe-Paganon S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149387 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ephrin type-A receptor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 82 amino acids
Theoretical weight: 9.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P21709 (Residues: 911-974; Coverage: 7%)
Gene names: EPH, EPHA1, EPHT, EPHT1
Sequence domains: SAM domain (Sterile alpha motif)
Structure domains: Transcription Factor, Ets-1

Ligands and Environments

2 bound ligands:
Ligand CL 1 x CL
Ligand NO3 1 x NO3
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P3121
Unit cell:
a: 52.286Å b: 52.286Å c: 81.307Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.212 0.208 0.279
Expression system: Escherichia coli

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