Function and Biology Details
Reactions catalysed:
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH
Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein]
Acetyl-CoA + n malonyl-CoA + 2n NADPH = long-chain-acyl-CoA + n CoA + n CO(2) + 2n NADP(+)
An acyl-[acyl-carrier protein] + NAD(+) = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH
Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein]
Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein]
Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl-carrier-protein] + oleate
A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H(2)O
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero hexamer (preferred)
Assembly name:
Fatty acid synthase (preferred)
PDBe Complex ID:
PDB-CPX-139403 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fatty acid synthase subunit alpha
Molecule details ›
Chains: A, B, C
Length: 1887 amino acids
Theoretical weight: 207.18 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Not provided
UniProt:
Sequence domains:
Length: 1887 amino acids
Theoretical weight: 207.18 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Not provided
UniProt:
- Canonical:
P19097 (Residues: 1-1887; Coverage: 100%)
Sequence domains:
Fatty acid synthase subunit beta
Molecule details ›
Chains: G, H, I
Length: 2051 amino acids
Theoretical weight: 228.94 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Not provided
UniProt:
Sequence domains:
Length: 2051 amino acids
Theoretical weight: 228.94 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Not provided
UniProt:
- Canonical: P07149 (Residues: 1-2051; Coverage: 100%)
Sequence domains:
- N-terminal domain in fatty acid synthase subunit beta
- Starter unit:ACP transacylase in aflatoxin biosynthesis
- Fatty acid synthase subunit beta/Fas1-like, helical
- Fatty acid synthase meander beta sheet domain
- N-terminal half of MaoC dehydratase
- MaoC like domain
- Acyl transferase domain
- Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2
- Malonyl-Coenzyme A Acyl Carrier Protein, domain 2
- Alpha-Beta Plaits
- Aldolase class I
- Transcription Elongation Factor S-II; Chain A
- Arylsulfatase, C-terminal domain
- Hotdog Thioesterase
- Lipocalin
- Hydrophobic Seed Protein
- Alpha-Beta Plaits
- Helix Hairpins
