› 3hmw

X-ray diffraction
3Å resolution

Crystal structure of ustekinumab FAB

Released:
DOI: 10.2210/pdb3hmw/pdb
PDB entry 3hmw coloured by chain, front view.
PDB entry 3hmw coloured by chain, side view.
PDB entry 3hmw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the dual recognition of IL-12 and IL-23 by ustekinumab.
Luo J, Wu SJ, Lacy ER, Orlovsky Y, Baker A, Teplyakov A, Obmolova G, Heavner GA, Richter HT, Benson J
J Mol Biol 402 797-812 (2010)
PMID: 20691190

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213270 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
USTEKINUMAB FAB LIGHT CHAIN Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.47 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
USTEKINUMAB FAB HEAVY CHAIN Chain: H
Molecule details ›
Chain: H
Length: 226 amino acids
Theoretical weight: 24.36 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand CD 2 x CD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P6322
Unit cell:
a: 139.31Å b: 139.31Å c: 114.58Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.231 0.228 0.287
Expression system: Homo sapiens

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Citations

26 review citations

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Lynde et al. (2014)
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8 mentions without citation

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Vreven et al. (2015)
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