› 3hp3

X-ray diffraction
2.2Å resolution

Crystal structure of CXCL12

Released:
DOI: 10.2210/pdb3hp3/pdb
PDB entry 3hp3 coloured by chain, front view.
PDB entry 3hp3 coloured by chain, side view.
PDB entry 3hp3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Heterologous quaternary structure of CXCL12 and its relationship to the CC chemokine family.
Murphy JW, Yuan H, Kong Y, Xiong Y, Lolis EJ
Proteins 78 1331-7 (2010)
PMID: 20077567

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155706 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stromal cell-derived factor 1 Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 68 amino acids
Theoretical weight: 7.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P48061 (Residues: 22-88; Coverage: 93%)
Gene names: CXCL12, SDF1, SDF1A, SDF1B
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

1 bound ligand:
Ligand AU 12 x AU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P212121
Unit cell:
a: 41.834Å b: 117.468Å c: 134.501Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.228 0.28
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Diversity and Inter-Connections in the CXCR4 Chemokine Receptor/Ligand Family: Molecular Perspectives.
Pawig et al. (2015)
7 more

4 mentions without citation

Structural NMR of protein oligomers using hybrid methods.
Wang et al. (2011)
3 more