› 3hro

X-ray diffraction
1.9Å resolution

Crystal structure of a C-terminal coiled coil domain of Transient receptor potential (TRP) channel subfamily P member 2 (TRPP2, polycystic kidney disease 2)

Released:
DOI: 10.2210/pdb3hro/pdb
PDB entry 3hro coloured by chain, front view.
PDB entry 3hro coloured by chain, side view.
PDB entry 3hro coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and molecular basis of the assembly of the TRPP2/PKD1 complex.
Yu Y, Ulbrich MH, Li MH, Buraei Z, Chen XZ, Ong AC, Tong L, Isacoff EY, Yang J
Proc Natl Acad Sci U S A 106 11558-63 (2009)
PMID: 19556541

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171760 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Polycystin-2 Chain: A
Molecule details ›
Chain: A
Length: 44 amino acids
Theoretical weight: 5.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13563 (Residues: 833-872; Coverage: 4%)
Gene names: PKD2, TRPP2
Sequence domains: Ferredoxin I 4Fe-4S cluster domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: P63
Unit cell:
a: 32.388Å b: 32.388Å c: 70.3Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.217 0.194 0.227
Expression system: Escherichia coli

Quick links

Citations

41 review citations

International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family.
Wu et al. (2010)
40 more

7 mentions without citation

Macromolecular ab initio phasing enforcing secondary and tertiary structure.
Millán et al. (2015)
6 more