› 3hsm

X-ray diffraction
2.5Å resolution

Crystal structure of distal N-terminal beta-trefoil domain of Ryanodine Receptor type 1

Released:
DOI: 10.2210/pdb3hsm/pdb
PDB entry 3hsm coloured by chain, front view.
PDB entry 3hsm coloured by chain, side view.
PDB entry 3hsm coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Crystal structure of type I ryanodine receptor amino-terminal beta-trefoil domain reveals a disease-associated mutation "hot spot" loop.
Amador FJ, Liu S, Ishiyama N, Plevin MJ, Wilson A, MacLennan DH, Ikura M
Proc Natl Acad Sci U S A 106 11040-4 (2009)
PMID: 19541610

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145900 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ryanodine receptor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 213 amino acids
Theoretical weight: 23.28 KDa
Source organism: Oryctolagus cuniculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P11716 (Residues: 1-210; Coverage: 4%)
Gene name: RYR1
Sequence domains: Inositol 1,4,5-trisphosphate/ryanodine receptor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: C2
Unit cell:
a: 140.597Å b: 35.299Å c: 78.94Å
α: 90° β: 99.37° γ: 90°
R-values:
R R work R free
0.229 0.229 0.276
Expression system: Escherichia coli

Quick links

Citations

20 review citations

Inherited dysfunction of sarcoplasmic reticulum Ca2+ handling and arrhythmogenesis.
Priori et al. (2011)
19 more

5 mentions without citation

Ryanodine receptors: structure, expression, molecular details, and function in calcium release.
Lanner et al. (2010)
4 more