› 3hup

X-ray diffraction
1.37Å resolution

High-resolution structure of the extracellular domain of human CD69

Released:
DOI: 10.2210/pdb3hup/pdb
PDB entry 3hup coloured by chain, front view.
PDB entry 3hup coloured by chain, side view.
PDB entry 3hup coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The high-resolution structure of the extracellular domain of human CD69 using a novel polymer.
Kolenko P, Skálová T, Vanek O, Stepánková A, Dusková J, Hasek J, Bezouska K, Dohnálek J
Acta Crystallogr Sect F Struct Biol Cryst Commun 65 1258-60 (2009)
PMID: 20054122

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170445 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Early activation antigen CD69 Chains: A, B
Molecule details ›
Chains: A, B
Length: 130 amino acids
Theoretical weight: 15.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07108 (Residues: 70-199; Coverage: 65%)
Gene names: CD69, CLEC2C
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

2 bound ligands:
Ligand CL 5 x CL
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P61
Unit cell:
a: 86.067Å b: 86.067Å c: 61.975Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.135 0.133 0.184
Expression system: Escherichia coli

Quick links

Citations

1 review citation

CD69 is the crucial regulator of intestinal inflammation: a new target molecule for IBD treatment?
Radulovic et al. (2015)
6 other articles

5 mentions without citation

Characterization of alternatively spliced transcript variants of CLEC2D gene.
Germain et al. (2010)
4 more