› 3i2t

X-ray diffraction
2.7Å resolution

Crystal structure of the unliganded Drosophila Epidermal Growth Factor Receptor ectodomain

Released:
DOI: 10.2210/pdb3i2t/pdb
PDB entry 3i2t coloured by chain, front view.
PDB entry 3i2t coloured by chain, side view.
PDB entry 3i2t coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor.
Alvarado D, Klein DE, Lemmon MA
Nature 461 287-91 (2009)
PMID: 19718021

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137627 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (5 distinct):
Epidermal growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 551 amino acids
Theoretical weight: 62.45 KDa
Source organism: Drosophila melanogaster
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P04412 (Residues: 100-644; Coverage: 39%)
Gene names: CG10079, DER, Egfr, c-erbB, top
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NDG, NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NDG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: C2221
Unit cell:
a: 74.378Å b: 174.798Å c: 161.653Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.224 0.264
Expression system: Spodoptera frugiperda

Quick links

Citations

13 review citations

Targeting the ERBB family in cancer: couples therapy.
Tebbutt et al. (2013)
12 more

8 mentions without citation

The EGFR family: not so prototypical receptor tyrosine kinases.
Lemmon et al. (2014)
7 more