› 3i5s

X-ray diffraction
3Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151131 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 3-kinase regulatory subunit alpha Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 83 amino acids
Theoretical weight: 9.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P27986 (Residues: 1-83; Coverage: 12%)
Gene names: GRB1, PIK3R1
Structure domains: SH3 Domains

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P21
Unit cell:
a: 49.333Å b: 61.049Å c: 61.014Å
α: 90° β: 111.38° γ: 90°
R-values:
R R work R free
0.243 0.24 0.299
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Multiple roles for the p85α isoform in the regulation and function of PI3K signalling and receptor trafficking.
Mellor et al. (2012)
1 more

6 mentions without citation

Regulation of the PI3K pathway through a p85α monomer-homodimer equilibrium.
Cheung et al. (2015)
5 more