› 3ifd

X-ray diffraction
1.9Å resolution

Human synthetic monocyte chemoattractant protein 1 (MCP-1)

Released:
DOI: 10.2210/pdb3ifd/pdb
PDB entry 3ifd coloured by chain, front view.
PDB entry 3ifd coloured by chain, side view.
PDB entry 3ifd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Synthesis by native chemical ligation and crystal structure of human CCL2.
Grygiel TL, Teplyakov A, Obmolova G, Stowell N, Holland R, Nemeth JF, Pomerantz SC, Kruszynski M, Gilliland GL
Biopolymers 94 350-9 (2010)
PMID: 20091676

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146616 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-C motif chemokine 2 Chain: A
Molecule details ›
Chain: A
Length: 76 amino acids
Theoretical weight: 8.7 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P13500 (Residues: 24-99; Coverage: 100%)
Gene names: CCL2, MCP1, SCYA2
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

2 bound ligands:
Ligand K 1 x K
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P3221
Unit cell:
a: 60.71Å b: 60.71Å c: 45.49Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.195 0.193 0.255
Expression system: Not provided

Quick links

Citations

2 review citations

9-Fluorenylmethoxycarbonyl-based solid-phase synthesis of peptide α-thioesters.
Mende et al. (2011)
1 more

11 mentions without citation

The marriage of chemokines and galectins as functional heterodimers.
von Hundelshausen et al. (2021)
10 more