› 3ikk

X-ray diffraction
2.5Å resolution

Crystal structure analysis of msp domain

Released:
DOI: 10.2210/pdb3ikk/pdb
PDB entry 3ikk coloured by chain, front view.
PDB entry 3ikk coloured by chain, side view.
PDB entry 3ikk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Elimination of the native structure and solubility of the hVAPB MSP domain by the Pro56Ser mutation that causes amyotrophic lateral sclerosis.
Shi J, Lua S, Tong JS, Song J
Biochemistry 49 3887-97 (2010)
PMID: 20377183

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131887 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Vesicle-associated membrane protein-associated protein B/C Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 14.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95292 (Residues: 1-125; Coverage: 51%)
Gene names: UNQ484/PRO983, VAPB
Sequence domains: MSP (Major sperm protein) domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER AXS MICROSTAR
Spacegroup: R3
Unit cell:
a: 144.024Å b: 144.024Å c: 34.791Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.213 0.207 0.266
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Autophagy and Neurodegeneration: Insights from a Cultured Cell Model of ALS.
Navone et al. (2015)
6 more

8 mentions without citation

ChSeq: A database of chameleon sequences.
Li et al. (2015)
7 more