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Crystal structure of TNF alpha complexed with a poxvirus MHC-related TNF binding protein

Source organisms:
Biochemical function: peptidase activity
Biological process: proteolysis
Cellular component: membrane

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF21584
Domain description: Poxvirus, 2L, N-terminal domain
Occurring in:
  1. Ig-like domain-containing protein
The deposited structure of PDB entry 3it8 contains 6 copies of Pfam domain PF21584 (Poxvirus, 2L, N-terminal domain) in Ig-like domain-containing protein. Showing 1 copy in chain D.

PF00229
Domain description: TNF(Tumour Necrosis Factor) family
Occurring in:
  1. Tumor necrosis factor, soluble form
The deposited structure of PDB entry 3it8 contains 6 copies of Pfam domain PF00229 (TNF(Tumour Necrosis Factor) family ) in Tumor necrosis factor, soluble form. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006053
Domain description: Tumour necrosis factor
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR006052
Domain description: Tumour necrosis factor domain
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR002959
Domain description: Tumour necrosis factor alpha
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR008983
Domain description: Tumour necrosis factor-like domain superfamily
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Ig-like domain-containing protein
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Ig-like domain-containing protein
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Ig-like domain-containing protein
IPR037055
Domain description: MHC class I-like antigen recognition-like superfamily
Occurring in:
  1. Ig-like domain-containing protein
IPR021184
Domain description: Tumour necrosis factor, conserved site
Occurring in:
  1. Tumor necrosis factor, soluble form

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Ig-like domain-containing protein
The deposited structure of PDB entry 3it8 contains 6 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Ig-like domain-containing protein. Showing 1 copy in chain D.
3.30.500.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1
Homology: MHC class I-like antigen recognition-like
Occurring in:
  1. Ig-like domain-containing protein
The deposited structure of PDB entry 3it8 contains 6 copies of CATH domain 3.30.500.10 (Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1) in Ig-like domain-containing protein. Showing 1 copy in chain D.
2.60.120.40
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Jelly Rolls
Occurring in:
  1. Tumor necrosis factor, soluble form
The deposited structure of PDB entry 3it8 contains 6 copies of CATH domain 2.60.120.40 (Jelly Rolls) in Tumor necrosis factor, soluble form. Showing 1 copy in chain A.

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