› 3jd6

Electron Microscopy
4.1Å resolution

Double octamer structure of retinoschisin, a cell-cell adhesion protein of the retina

Released:
DOI: 10.2210/pdb3jd6/pdb
PDB entry 3jd6 coloured by chain, front view.
PDB entry 3jd6 coloured by chain, side view.
PDB entry 3jd6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Paired octamer rings of retinoschisin suggest a junctional model for cell-cell adhesion in the retina.
Tolun G, Vijayasarathy C, Huang R, Zeng Y, Li Y, Steven AC, Sieving PA, Heymann JB
Proc Natl Acad Sci U S A 113 5287-92 (2016)
PMID: 27114531
Related structures: EMD-6425

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127522 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinoschisin Chain: O
Molecule details ›
Chain: O
Length: 207 amino acids
Theoretical weight: 23.89 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O15537 (Residues: 24-224; Coverage: 100%)
Gene names: RS1, XLRS1
Sequence domains: F5/8 type C domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.1Å
Relevant EMDB volumes: EMD-6425
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

The internal limiting membrane: Roles in retinal development and implications for emerging ocular therapies.
Zhang et al. (2021)
1 more

6 mentions without citation

Paired octamer rings of retinoschisin suggest a junctional model for cell-cell adhesion in the retina.
Tolun et al. (2016)
5 more