› 3jd8

Electron Microscopy
4.43Å resolution

cryo-EM structure of the full-length human NPC1 at 4.4 angstrom

Released:
DOI: 10.2210/pdb3jd8/pdb
PDB entry 3jd8 coloured by chain, front view.
PDB entry 3jd8 coloured by chain, side view.
PDB entry 3jd8 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Gong X, Qian HW, Zhou XH, Wu JP, Zhou Q, Yan N
Related structures: EMD-6640

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127297 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
NPC intracellular cholesterol transporter 1 Chain: A
Molecule details ›
Chain: A
Length: 1278 amino acids
Theoretical weight: 142.27 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O15118 (Residues: 1-1278; Coverage: 100%)
Gene name: NPC1
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
2 bound ligands:
Ligand NAG 11 x NAG
Ligand CLR 1 x CLR
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.43Å
Relevant EMDB volumes: EMD-6640
Expression system: Homo sapiens

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