› 3jve

X-ray diffraction
1.34Å resolution

Crystal Structure of the Sixth BRCT Domain of TopBP1

Released:
DOI: 10.2210/pdb3jve/pdb
PDB entry 3jve coloured by chain, front view.
PDB entry 3jve coloured by chain, side view.
PDB entry 3jve coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Insights from the crystal structure of the sixth BRCT domain of topoisomerase IIbeta binding protein 1.
Leung CC, Kellogg E, Kuhnert A, Hänel F, Baker D, Glover JN
Protein Sci 19 162-7 (2010)
PMID: 19937654

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA topoisomerase 2-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 109 amino acids
Theoretical weight: 12.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92547 (Residues: 893-996; Coverage: 7%)
Gene names: KIAA0259, TOPBP1
Sequence domains: BRCA1 C Terminus (BRCT) domain
Structure domains: BRCT domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P212121
Unit cell:
a: 35.767Å b: 51.824Å c: 62.086Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.159 0.158 0.173
Expression system: Escherichia coli

Quick links

Citations

4 review citations

TopBP1: A BRCT-scaffold protein functioning in multiple cellular pathways.
Wardlaw et al. (2014)
3 more

4 mentions without citation

BRCT domains: easy as one, two, three.
Leung et al. (2011)
3 more