› 3jxh

X-ray diffraction
1.7Å resolution

CA-like domain of human PTPRG

Released:
DOI: 10.2210/pdb3jxh/pdb
PDB entry 3jxh coloured by chain, front view.
PDB entry 3jxh coloured by chain, side view.
PDB entry 3jxh coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules.
Bouyain S, Watkins DJ
Proc Natl Acad Sci U S A 107 2443-8 (2010)
PMID: 20133774

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149980 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type tyrosine-protein phosphatase gamma Chain: C
Molecule details ›
Chain: C
Length: 265 amino acids
Theoretical weight: 30.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P23470 (Residues: 56-320; Coverage: 19%)
Gene names: PTPG, PTPRG
Sequence domains: Eukaryotic-type carbonic anhydrase
Structure domains: Alpha carbonic anhydrase

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 52.543Å b: 66.17Å c: 86.764Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.178 0.193
Expression system: Escherichia coli

Quick links

Citations

24 review citations

Protein tyrosine phosphatases in health and disease.
Hendriks et al. (2013)
23 more

2 mentions without citation

The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules.
Bouyain et al. (2010)
1 more