› 3jyc

X-ray diffraction
3.11Å resolution

Crystal structure of the eukaryotic strong inward-rectifier K+ channel Kir2.2 at 3.1 Angstrom resolution

Released:
DOI: 10.2210/pdb3jyc/pdb
PDB entry 3jyc coloured by chain, front view.
PDB entry 3jyc coloured by chain, side view.
PDB entry 3jyc coloured by chain, top view.
Source organism: Gallus gallus
Primary publication:
Crystal structure of the eukaryotic strong inward-rectifier K+ channel Kir2.2 at 3.1 A resolution.
Tao X, Avalos JL, Chen J, MacKinnon R
Science 326 1668-74 (2009)
PMID: 20019282

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-123320 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP-sensitive inward rectifier potassium channel 12 Chain: A
Molecule details ›
Chain: A
Length: 343 amino acids
Theoretical weight: 39.36 KDa
Source organism: Gallus gallus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: F1NHE9 (Residues: 37-372; Coverage: 78%)
Gene name: KCNJ12
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand K 5 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: I4
Unit cell:
a: 84.018Å b: 84.018Å c: 196.121Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.242 0.27
Expression system: Komagataella pastoris

Quick links

Citations

43 review citations

Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease.
Lüscher et al. (2010)
42 more

72 mentions without citation

Phosphoinositides regulate ion channels.
Hille et al. (2015)
71 more