› 3k91

X-ray diffraction
1.75Å resolution

Polysulfane Bridge in Cu-Zn Superoxide Dismutase

Released:
DOI: 10.2210/pdb3k91/pdb
PDB entry 3k91 coloured by chain, front view.
PDB entry 3k91 coloured by chain, side view.
PDB entry 3k91 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Characterization of a covalent polysulfane bridge in copper-zinc superoxide dismutase .
You Z, Cao X, Taylor AB, Hart PJ, Levine RL
Biochemistry 49 1191-8 (2010)
PMID: 20052996

Function and Biology Details

Reaction catalysed: 
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132494 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Superoxide dismutase [Cu-Zn] Chains: A, B
Molecule details ›
Chains: A, B
Length: 153 amino acids
Theoretical weight: 15.84 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P00441 (Residues: 2-154; Coverage: 99%)
Gene name: SOD1
Sequence domains: Copper/zinc superoxide dismutase (SODC)
Structure domains: Superoxide dismutase, copper/zinc binding domain

Ligands and Environments

1 bound ligand:
Ligand PS5 1 x PS5
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P212121
Unit cell:
a: 40.049Å b: 57.925Å c: 104.988Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.188 0.218
Expression system: Saccharomyces cerevisiae

Quick links

Citations

10 review citations

Chemical Biology of H2S Signaling through Persulfidation.
Filipovic et al. (2018)
9 more

5 mentions without citation

Structural Properties and Interaction Partners of Familial ALS-Associated SOD1 Mutants.
Huai et al. (2019)
4 more