› 3kat

X-ray diffraction
3.1Å resolution

Crystal Structure of the CARD domain of the human NLRP1 protein, Northeast Structural Genomics Consortium Target HR3486E

Released:
DOI: 10.2210/pdb3kat/pdb
PDB entry 3kat coloured by chain, front view.
PDB entry 3kat coloured by chain, side view.
PDB entry 3kat coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Forouhar F, Abashidze M, Seetharaman J, Mao M, Xiao R, Ciccosanti C, Shastry R, Everett JK, Nair R, Acton TB, Rost B, Montelione GT, Tong L, Hunt JF, Northeast Structural Genomics Consortium (NESG)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-189873 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NACHT, LRR and PYD domains-containing protein 1, C-terminus Chain: A
Molecule details ›
Chain: A
Length: 107 amino acids
Theoretical weight: 12.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9C000 (Residues: 1371-1467; Coverage: 7%)
Gene names: CARD7, DEFCAP, KIAA0926, NAC, NALP1, NLRP1
Sequence domains: Caspase recruitment domain
Structure domains: Death Domain, Fas

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 3 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P41212
Unit cell:
a: 40.708Å b: 40.708Å c: 160.413Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.202 0.26
Expression system: Escherichia coli BL21(DE3)

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