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Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pY-E-N-NH2 Tripeptide Mimic

X-ray diffraction
2.02Å resolution
PDB entry 3kfj coloured by chain, front view.
PDB entry 3kfj coloured by chain, side view.
PDB entry 3kfj coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Growth factor receptor-bound protein 2
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Multimeric state: monomeric
Accessible surface area: 6131.74 Å2
Buried surface area: 367.31 Å2
Dissociation area: 48.91 Å2
Dissociation energy (ΔGdiss): 8.51 kcal/mol
Dissociation entropy (TΔSdiss): -1.47 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-158852
Assembly 2
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Assembly Name: Growth factor receptor-bound protein 2
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Multimeric state: homo dimer
Accessible surface area: 10155.09 Å2
Buried surface area: 2848.41 Å2
Dissociation area: 1,056.52 Å2
Dissociation energy (ΔGdiss): 5.71 kcal/mol
Dissociation entropy (TΔSdiss): 11.29 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-158872

Macromolecules

Growth factor receptor-bound protein 2
Chain: A
Length: 117 amino acids
Theoretical weight: 13.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62993 (Residues: 53-163; Coverage: 51%)
Gene names: ASH, GRB2
Pfam: SH2 domain
InterPro:
CATH: SH2 domain
Growth factor receptor-bound protein 2 in PDB entry 3kfj, assembly 1, front view.
Growth factor receptor-bound protein 2 in PDB entry 3kfj, assembly 1, side view.
Growth factor receptor-bound protein 2 in PDB entry 3kfj, assembly 1, top view.
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