› 3kg5

X-ray diffraction
3.2Å resolution

Crystal structure of human Ig-beta homodimer

Released:
DOI: 10.2210/pdb3kg5/pdb
PDB entry 3kg5 coloured by chain, front view.
PDB entry 3kg5 coloured by chain, side view.
PDB entry 3kg5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional studies of Igalphabeta and its assembly with the B cell antigen receptor.
Radaev S, Zou Z, Tolar P, Nguyen K, Nguyen A, Krueger PD, Stutzman N, Pierce S, Sun PD
Structure 18 934-43 (2010)
PMID: 20696394

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154061 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
B-cell antigen receptor complex-associated protein beta chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 134 amino acids
Theoretical weight: 15.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P40259 (Residues: 26-159; Coverage: 65%)
Gene names: B29, CD79B, IGB
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P4132
Unit cell:
a: 129.8Å b: 129.8Å c: 129.8Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.181 0.263
Expression system: Escherichia coli

Quick links

Citations

7 review citations

The tipping points in the initiation of B cell signalling: how small changes make big differences.
Pierce et al. (2010)
6 more

4 mentions without citation

Designing Multi-Epitope Vaccines to Combat Emerging Coronavirus Disease 2019 (COVID-19) by Employing Immuno-Informatics Approach.
Naz et al. (2020)
3 more