› 3kgc

X-ray diffraction
1.55Å resolution

Isolated ligand binding domain dimer of GluA2 ionotropic glutamate receptor in complex with glutamate, LY 404187 and ZK 200775

Released:
DOI: 10.2210/pdb3kgc/pdb
PDB entry 3kgc coloured by chain, front view.
PDB entry 3kgc coloured by chain, side view.
PDB entry 3kgc coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor.
Sobolevsky AI, Rosconi MP, Gouaux E
Nature 462 745-56 (2009)
PMID: 19946266

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 263 amino acids
Theoretical weight: 29.19 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19491 (Residues: 414-527, 634-796; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

4 bound ligands:
Ligand GLU 1 x GLU
Ligand SO4 2 x SO4
Ligand LY7 1 x LY7
Ligand ZK1 1 x ZK1
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 66.657Å b: 95.586Å c: 97.047Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.198 0.196 0.224
Expression system: Escherichia coli

Quick links

Citations

149 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
148 more

11 mentions without citation

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.
Hansen et al. (2021)
10 more