› 3kk9

X-ray diffraction
3.21Å resolution

CaMKII Substrate Complex B

Released:
DOI: 10.2210/pdb3kk9/pdb
PDB entry 3kk9 coloured by chain, front view.
PDB entry 3kk9 coloured by chain, side view.
PDB entry 3kk9 coloured by chain, top view.
Source organism: Caenorhabditis elegans
Primary publication:
Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation.
Chao LH, Pellicena P, Deindl S, Barclay LA, Schulman H, Kuriyan J
Nat Struct Mol Biol 17 264-72 (2010)
PMID: 20139983

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130252 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium/calmodulin-dependent protein kinase type II Chain: A
Molecule details ›
Chain: A
Length: 282 amino acids
Theoretical weight: 32 KDa
Source organism: Caenorhabditis elegans
Expression system: Escherichia coli
UniProt:
  • Canonical: O62305 (Residues: 6-287; Coverage: 39%)
Gene names: K11E8.1, unc-43
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand TPO 1 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P21
Unit cell:
a: 37.708Å b: 60.47Å c: 70.243Å
α: 90° β: 93.92° γ: 90°
R-values:
R R work R free
0.272 0.27 0.329
Expression system: Escherichia coli

Quick links

Citations

19 review citations

The structural basis for control of eukaryotic protein kinases.
Endicott et al. (2012)
18 more

4 mentions without citation

Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II.
Stratton et al. (2013)
3 more