Function and Biology Details
Reactions catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assemblies composition:
Assembly name:
Integrase (preferred)
PDBe Complex ID:
PDB-CPX-148642 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrase
Molecule details ›
Chain: A
Length: 152 amino acids
Theoretical weight: 17.07 KDa
Source organism: Bovine immunodeficiency virus R29
Expression system: Escherichia coli
UniProt:
Sequence domains: Integrase core domain
Structure domains: Ribonuclease H-like superfamily/Ribonuclease H
Length: 152 amino acids
Theoretical weight: 17.07 KDa
Source organism: Bovine immunodeficiency virus R29
Expression system: Escherichia coli
UniProt:
- Canonical:
P19560 (Residues: 1257-1405; Coverage: 10%)
Sequence domains: Integrase core domain
Structure domains: Ribonuclease H-like superfamily/Ribonuclease H
