› 3kmd

X-ray diffraction
2.15Å resolution

Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer

Released:
DOI: 10.2210/pdb3kmd/pdb
PDB entry 3kmd coloured by chain, front view.
PDB entry 3kmd coloured by chain, side view.
PDB entry 3kmd coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the p53 core domain bound to a full consensus site as a self-assembled tetramer.
Chen Y, Dey R, Chen L
Structure 18 246-56 (2010)
PMID: 20159469

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-116491 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Cellular tumor antigen p53 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 200 amino acids
Theoretical weight: 22.53 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P04637 (Residues: 92-291; Coverage: 51%)
Gene names: P53, TP53
Sequence domains: P53 DNA-binding domain
Structure domains: Immunoglobulin-like
5'-D(*GP*GP*GP*CP*AP*TP*GP*CP*CP*TP*AP*GP*GP*CP*AP*TP*GP*CP*C)-3' Chains: E, F
Molecule details ›
Chains: E, F
Length: 19 nucleotides
Theoretical weight: 5.85 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P212121
Unit cell:
a: 65.084Å b: 93.713Å c: 145.57Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.216 0.24
Expression system: Not provided

Quick links

Citations

9 review citations

The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches.
Joerger et al. (2016)
8 more

28 mentions without citation

DNA Charge Transport: from Chemical Principles to the Cell.
Arnold et al. (2016)
27 more