› 3kq0

X-ray diffraction
1.8Å resolution

Crystal structure of human alpha1-acid glycoprotein

Released:
DOI: 10.2210/pdb3kq0/pdb
PDB entry 3kq0 coloured by chain, front view.
PDB entry 3kq0 coloured by chain, side view.
PDB entry 3kq0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The 1.8-A crystal structure of alpha1-acid glycoprotein (Orosomucoid) solved by UV RIP reveals the broad drug-binding activity of this human plasma lipocalin.
Schönfeld DL, Ravelli RB, Mueller U, Skerra A
J Mol Biol 384 393-405 (2008)
PMID: 18823996

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136162 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-1-acid glycoprotein 1 Chain: A
Molecule details ›
Chain: A
Length: 192 amino acids
Theoretical weight: 22.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02763 (Residues: 19-201; Coverage: 100%)
Gene names: AGP1, ORM1
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

2 bound ligands:
Ligand JIM 1 x JIM
Ligand CL 1 x CL
1 modified residue:
Ligand PCA 1 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1, BESSY BEAMLINE 14.1
Spacegroup: P41212
Unit cell:
a: 78.894Å b: 78.894Å c: 93.384Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.202 0.24
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Interactive association of drugs binding to human serum albumin.
Yang et al. (2014)
10 more

24 mentions without citation

Photoaffinity labeling of plasma proteins.
Chuang et al. (2013)
23 more