Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Cubilin and Cobalamin binding intrinsic factor (preferred)
PDBe Complex ID:
PDB-CPX-129995 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Cobalamin binding intrinsic factor
Molecule details ›
Chains: A, C, E
Length: 393 amino acids
Theoretical weight: 42.82 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
Sequence domains: Eukaryotic cobalamin-binding protein
Structure domains:
Length: 393 amino acids
Theoretical weight: 42.82 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
- Canonical:
P27352 (Residues: 25-417; Coverage: 99%)
Sequence domains: Eukaryotic cobalamin-binding protein
Structure domains:
Cubilin
Molecule details ›
Chains: B, D, F
Length: 457 amino acids
Theoretical weight: 51.63 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
Sequence domains: CUB domain
Structure domains: Spermadhesin, CUB domain
Length: 457 amino acids
Theoretical weight: 51.63 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
- Canonical: O60494 (Residues: 932-1388; Coverage: 13%)
Sequence domains: CUB domain
Structure domains: Spermadhesin, CUB domain
Ligands and Environments
No modified residues
Experiments and Validation Details
X-ray source:
SLS BEAMLINE X06SA, MAX II BEAMLINE I911-3
Spacegroup:
C2221
Expression systems:
- Komagataella pastoris
- Cricetulus griseus
