› 3kq7

X-ray diffraction
1.8Å resolution

Structure of human p38alpha with N-[4-methyl-3-(6-{[2-(1-methylpyrrolidin-2-yl)ethyl]amino}pyridine-3-amido)phenyl]-2-(morpholin-4-yl)pyridine-4-carboxamide

Released:
DOI: 10.2210/pdb3kq7/pdb
PDB entry 3kq7 coloured by chain, front view.
PDB entry 3kq7 coloured by chain, side view.
PDB entry 3kq7 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Cheng RKY, Barker J, Whittaker M

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172487 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 380 amino acids
Theoretical weight: 43.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16539 (Residues: 1-360; Coverage: 100%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand KQ7 1 x KQ7
Ligand ACT 5 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P212121
Unit cell:
a: 45.427Å b: 84.354Å c: 125.508Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.188 0.233
Expression system: Escherichia coli

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