› 3kuq

X-ray diffraction
2.3Å resolution

Crystal structure of the DLC1 RhoGAP domain

Released:
DOI: 10.2210/pdb3kuq/pdb
PDB entry 3kuq coloured by chain, front view.
PDB entry 3kuq coloured by chain, side view.
PDB entry 3kuq coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Nedyalkova L, Tempel W, Tong Y, MacKenzie F, Shen L, Zhong N, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188693 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rho GTPase-activating protein 7 Chain: A
Molecule details ›
Chain: A
Length: 228 amino acids
Theoretical weight: 26.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q96QB1 (Residues: 1074-1283; Coverage: 14%)
Gene names: ARHGAP7, DLC1, KIAA1723, STARD12
Sequence domains: RhoGAP domain
Structure domains: Rho GTPase activation protein

Ligands and Environments

1 bound ligand:
Ligand UNX 4 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2221
Unit cell:
a: 60.577Å b: 97.502Å c: 92.577Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.216 0.26
Expression system: Escherichia coli BL21

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