› 3kvo

X-ray diffraction
2.25Å resolution

Crystal structure of the catalytic domain of human Hydroxysteroid dehydrogenase like 2 (HSDL2)

Released:
DOI: 10.2210/pdb3kvo/pdb
PDB entry 3kvo coloured by chain, front view.
PDB entry 3kvo coloured by chain, side view.
PDB entry 3kvo coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ugochukwu E, Bhatia C, Huang J, Pilka E, Muniz JRC, Pike ACW, Krojer T, von Delft F, Arrowsmith CH, Weigelt J, Edwards A, Bountra C, Verdin EM, Oppermann U, Kavanagh KL, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-180560 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hydroxysteroid dehydrogenase-like protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 346 amino acids
Theoretical weight: 37.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q6YN16 (Residues: 1-293; Coverage: 70%)
Gene names: C9orf99, HSDL2, SDR13C1
Sequence domains: short chain dehydrogenase
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments

1 bound ligand:
Ligand NAP 4 x NAP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P212121
Unit cell:
a: 61.149Å b: 78.332Å c: 121.765Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.199 0.247
Expression system: Escherichia coli BL21(DE3)

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