› 3kz7

X-ray diffraction
1.95Å resolution

C-terminal domain of Murine FKBP25 rapamycin complex

Released:
DOI: 10.2210/pdb3kz7/pdb
PDB entry 3kz7 coloured by chain, front view.
PDB entry 3kz7 coloured by chain, side view.
PDB entry 3kz7 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Diversified targets of FKBP25 and its complex with rapamycin.
Galat A, Thai R, Stura EA
Int J Biol Macromol 69 344-52 (2014)
PMID: 24879919

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178943 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase FKBP3 Chain: A
Molecule details ›
Chain: A
Length: 119 amino acids
Theoretical weight: 13.28 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q62446 (Residues: 106-224; Coverage: 53%)
Gene names: Fkbp25, Fkbp3
Sequence domains: FKBP-type peptidyl-prolyl cis-trans isomerase
Structure domains: Chitinase A; domain 3

Ligands and Environments

1 bound ligand:
Ligand RAP 1 x RAP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P41212
Unit cell:
a: 85.649Å b: 85.649Å c: 53.09Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.175 0.222
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Diverse structures, functions and uses of FK506 binding proteins.
Bonner et al. (2017)
2 more

1 mention without citation

Roles of Prolyl Isomerases in RNA-Mediated Gene Expression.
Thapar R. (2015)