› 3l15

X-ray diffraction
2Å resolution

Human Tead2 transcriptional factor

Released:
DOI: 10.2210/pdb3l15/pdb
PDB entry 3l15 coloured by chain, front view.
PDB entry 3l15 coloured by chain, side view.
PDB entry 3l15 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional analysis of the YAP-binding domain of human TEAD2.
Tian W, Yu J, Tomchick DR, Pan D, Luo X
Proc Natl Acad Sci U S A 107 7293-8 (2010)
PMID: 20368466

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172328 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcriptional enhancer factor TEF-4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 231 amino acids
Theoretical weight: 26.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15562 (Residues: 217-447; Coverage: 52%)
Gene names: TEAD2, TEF4
Sequence domains: YAP binding domain
Structure domains: Coagulation Factor XIII; Chain A, domain 1

Ligands and Environments

1 bound ligand:
Ligand GOL 3 x GOL
1 modified residue:
Ligand MSE 8 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: C2
Unit cell:
a: 121.144Å b: 61.567Å c: 80.472Å
α: 90° β: 117.27° γ: 90°
R-values:
R R work R free
0.192 0.188 0.244
Expression system: Escherichia coli

Quick links

Citations

29 review citations

The hippo signaling pathway in development and cancer.
Pan D. (2010)
28 more

9 mentions without citation

Recent Therapeutic Approaches to Modulate the Hippo Pathway in Oncology and Regenerative Medicine.
Barry et al. (2021)
8 more