› 3l43

X-ray diffraction
2.27Å resolution

Crystal structure of the dynamin 3 GTPase domain bound with GDP

Released:
DOI: 10.2210/pdb3l43/pdb
PDB entry 3l43 coloured by chain, front view.
PDB entry 3l43 coloured by chain, side view.
PDB entry 3l43 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Yang S, Tempel W, Tong Y, Nedyalkova L, Guan X, Crombet L, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194058 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dynamin-3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 319 amino acids
Theoretical weight: 35.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9UQ16 (Residues: 6-306; Coverage: 35%)
Gene names: DNM3, KIAA0820
Sequence domains:
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand GDP 4 x GDP
Ligand UNX 6 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E
Spacegroup: P21
Unit cell:
a: 49.286Å b: 166.5Å c: 74.985Å
α: 90° β: 109.02° γ: 90°
R-values:
R R work R free
0.23 0.229 0.269
Expression system: Escherichia coli BL21

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