› 3l5j

X-ray diffraction
3.04Å resolution

Crystal structure of FnIII domains of human GP130 (Domains 4-6)

Released:
DOI: 10.2210/pdb3l5j/pdb
PDB entry 3l5j coloured by chain, front view.
PDB entry 3l5j coloured by chain, side view.
PDB entry 3l5j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes.
Xu Y, Kershaw NJ, Luo CS, Soo P, Pocock MJ, Czabotar PE, Hilton DJ, Nicola NA, Garrett TP, Zhang JG
J Biol Chem 285 21214-8 (2010)
PMID: 20489211

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154044 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-6 receptor subunit beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 288 amino acids
Theoretical weight: 32.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P40189 (Residues: 323-610; Coverage: 32%)
Gene name: IL6ST
Sequence domains: Fibronectin type III domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand EDO 1 x EDO
Ligand CL 4 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: C2
Unit cell:
a: 102.936Å b: 89.221Å c: 106.877Å
α: 90° β: 117.72° γ: 90°
R-values:
R R work R free
0.213 0.213 0.265
Expression system: Escherichia coli

Quick links

Citations

15 review citations

The pro- and anti-inflammatory properties of the cytokine interleukin-6.
Scheller et al. (2011)
14 more

2 mentions without citation

Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes.
Xu et al. (2010)
1 more