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Structure of MHC class II molecule HLA-DR1 complexed with phosphopeptide MART-1

X-ray diffraction
2.1Å resolution
PDB entry 3l6f coloured by chain, front view.
PDB entry 3l6f coloured by chain, side view.
PDB entry 3l6f coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 17803.31 Å2
Buried surface area: 7614.51 Å2
Dissociation area: 1,214.76 Å2
Dissociation energy (ΔGdiss): 12.05 kcal/mol
Dissociation entropy (TΔSdiss): 8.74 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-135344

Macromolecules

HLA class II histocompatibility antigen, DR alpha chain
Chain: A
Length: 182 amino acids
Theoretical weight: 21.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01903 (Residues: 26-207; Coverage: 80%)
Gene names: HLA-DRA, HLA-DRA1
Pfam:
InterPro:
CATH:
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 3l6f, assembly 1, front view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 3l6f, assembly 1, side view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 3l6f, assembly 1, top view.
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HLA class II histocompatibility antigen, DRB1 beta chain
Chain: B
Length: 193 amino acids
Theoretical weight: 22.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01911 (Residues: 30-221; Coverage: 81%)
Gene name: HLA-DRB1
Pfam:
InterPro:
CATH:
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 3l6f, assembly 1, front view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 3l6f, assembly 1, side view.
HLA class II histocompatibility antigen, DRB1 beta chain in PDB entry 3l6f, assembly 1, top view.
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Melanoma antigen recognized by T-cells 1
Chain: C
Length: 15 amino acids
Theoretical weight: 1.67 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q16655 (Residues: 100-114; Coverage: 13%)
Gene names: MART1, MLANA
Melanoma antigen recognized by T-cells 1 in PDB entry 3l6f, assembly 1, front view.
Melanoma antigen recognized by T-cells 1 in PDB entry 3l6f, assembly 1, side view.
Melanoma antigen recognized by T-cells 1 in PDB entry 3l6f, assembly 1, top view.
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