Selection of a novel highly specific TNFalpha antagonist: Insight from the crystal structure of the antagonist-TNFalpha complex
Source organism:
Homo sapiens
Biochemical function:
tumor necrosis factor receptor binding
Biological process: immune response
Cellular component: membrane
Biological process: immune response
Cellular component: membrane
Protein families (Pfam)![The deposited structure of PDB entry 3l9j contains 1 copy of Pfam domain PF00229 (TNF(Tumour Necrosis Factor) family ) in Tumor necrosis factor, soluble form. Showing 1 copy in chain B [auth T].](https://www.ebi.ac.uk/pdbe/static/entry/3l9j_2_T_Pfam_PF00229_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>3l9j</span> contains 1 copy of Pfam domain <span class='highlight'>PF00229 (TNF(Tumour Necrosis Factor) family )</span> in <span class='highlight'>Tumor necrosis factor, soluble form</span>. Showing 1 copy in chain <span class='highlight'>B [auth T]</span>.")
![The deposited structure of PDB entry 3l9j contains 1 copy of Pfam domain PF00059 (Lectin C-type domain) in Tetranectin. Showing 1 copy in chain A [auth C].](https://www.ebi.ac.uk/pdbe/static/entry/3l9j_1_C_Pfam_PF00059_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>3l9j</span> contains 1 copy of Pfam domain <span class='highlight'>PF00059 (Lectin C-type domain)</span> in <span class='highlight'>Tetranectin</span>. Showing 1 copy in chain <span class='highlight'>A [auth C]</span>.")
InterPro annotations
CATH domains![The deposited structure of PDB entry 3l9j contains 1 copy of CATH domain 2.60.120.40 (Jelly Rolls) in Tumor necrosis factor, soluble form. Showing 1 copy in chain B [auth T].](https://www.ebi.ac.uk/pdbe/static/entry/3l9j_2_T_CATH_2.60.120.40_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>3l9j</span> contains 1 copy of CATH domain <span class='highlight'>2.60.120.40 (Jelly Rolls)</span> in <span class='highlight'>Tumor necrosis factor, soluble form</span>. Showing 1 copy in chain <span class='highlight'>B [auth T]</span>.")
![The deposited structure of PDB entry 3l9j contains 1 copy of CATH domain 3.10.100.10 (Mannose-Binding Protein A; Chain A) in Tetranectin. Showing 1 copy in chain A [auth C].](https://www.ebi.ac.uk/pdbe/static/entry/3l9j_1_C_CATH_3.10.100.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>3l9j</span> contains 1 copy of CATH domain <span class='highlight'>3.10.100.10 (Mannose-Binding Protein A; Chain A)</span> in <span class='highlight'>Tetranectin</span>. Showing 1 copy in chain <span class='highlight'>A [auth C]</span>.")