Function and Biology Details
Reactions catalysed:
ATP + [isocitrate dehydrogenase (NADP(+))] = ADP + [isocitrate dehydrogenase (NADP(+))] phosphate
(1a) isocitrate + NADP(+) = 2-oxalosuccinate + NADPH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Isocitrate dehydrogenase kinasephosphatase
- Isopropylmalate dehydrogenase-like domain
- Isocitrate/isopropylmalate dehydrogenase, conserved site
- Isocitrate dehydrogenase NADP-dependent, dimeric, prokaryotic
- Isocitrate dehydrogenase kinase/phosphatase (AceK), kinase domain
- Isocitrate dehydrogenase kinase/phosphatase (AceK), regulatory domain
Structure analysis Details
Assemblies composition:
Assembly name:
PDBe Complex ID:
PDB-CPX-140024 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Isocitrate dehydrogenase kinase/phosphatase
Molecule details ›
Chains: A, B
Length: 578 amino acids
Theoretical weight: 67.82 KDa
Source organism: Escherichia coli O157:H7
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 578 amino acids
Theoretical weight: 67.82 KDa
Source organism: Escherichia coli O157:H7
Expression system: Escherichia coli
UniProt:
- Canonical:
Q8X607 (Residues: 1-578; Coverage: 100%)
Sequence domains:
Isocitrate dehydrogenase [NADP]
Molecule details ›
Chains: C, D
Length: 416 amino acids
Theoretical weight: 45.81 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
Sequence domains: Isocitrate/isopropylmalate dehydrogenase
Structure domains: Isopropylmalate Dehydrogenase
Length: 416 amino acids
Theoretical weight: 45.81 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
- Canonical: P08200 (Residues: 1-416; Coverage: 100%)
Sequence domains: Isocitrate/isopropylmalate dehydrogenase
Structure domains: Isopropylmalate Dehydrogenase
