› 3lg3

X-ray diffraction
1.4Å resolution

1.4A Crystal Structure of Isocitrate Lyase from Yersinia pestis CO92

Released:
DOI: 10.2210/pdb3lg3/pdb
PDB entry 3lg3 coloured by chain, front view.
PDB entry 3lg3 coloured by chain, side view.
PDB entry 3lg3 coloured by chain, top view.
Source organism: Yersinia pestis
Entry authors: Sharma SS, Brunzelle JS, Skarina T, Savchenko A, Anderson WF, Center for Structural Genomics of Infectious Diseases (CSGID)

Function and Biology Details

Reaction catalysed: 
Isocitrate = succinate + glyoxylate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-104501 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Isocitrate lyase Chains: A, B
Molecule details ›
Chains: A, B
Length: 435 amino acids
Theoretical weight: 48.19 KDa
Source organism: Yersinia pestis
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A2S9PCG6 (Residues: 1-435; Coverage: 100%)
Gene names: YPO3725, aceA, icl
Sequence domains: Isocitrate lyase family
Structure domains: Phosphoenolpyruvate-binding domains

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 20 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: C2221
Unit cell:
a: 94.163Å b: 115.133Å c: 174.835Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.133 0.131 0.165
Expression system: Escherichia coli

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