› 3lh4

X-ray diffraction
1.8Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-110586 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Salivary cystatin-L2 Chain: A
Molecule details ›
Chain: A
Length: 115 amino acids
Theoretical weight: 12.78 KDa
Source organism: Ixodes scapularis
Expression system: Escherichia coli
UniProt:
  • Canonical: B7PKZ1 (Residues: 19-132; Coverage: 100%)
Gene name: IscW_ISCW018602
Sequence domains: Cystatin domain
Structure domains: Nuclear Transport Factor 2; Chain: A,

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: I23
Unit cell:
a: 95.451Å b: 95.451Å c: 95.451Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.173 0.196
Expression system: Escherichia coli

Quick links

Citations

16 review citations

Tick salivary compounds: their role in modulation of host defences and pathogen transmission.
Kazimírová et al. (2013)
15 more

8 mentions without citation

The role of cystatins in tick physiology and blood feeding.
Schwarz et al. (2012)
7 more