Function and Biology Details
Reaction catalysed:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- EF-hand domain
- Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
- EF-Hand 1, calcium-binding site
- Metallo-dependent phosphatase-like
- EF-hand domain pair
- Calcineurin B protein
- Calcineurin-like phosphoesterase domain, ApaH type
- PP2B, metallophosphatase domain
1 more domain
Structure analysis Details
Assemblies composition:
PDBe Complex ID:
PDB-CPX-150249 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
A-kinase anchor protein 5
Molecule details ›
Chain: E
Length: 11 amino acids
Theoretical weight: 1.21 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Length: 11 amino acids
Theoretical weight: 1.21 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical:
P24588 (Residues: 336-346; Coverage: 3%)
Protein phosphatase 3 catalytic subunit alpha
Molecule details ›
Chains: A, C
Length: 357 amino acids
Theoretical weight: 41.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Calcineurin-like phosphoesterase
Structure domains: Purple Acid Phosphatase; chain A, domain 2
Length: 357 amino acids
Theoretical weight: 41.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q08209 (Residues: 14-370; Coverage: 69%)
Sequence domains: Calcineurin-like phosphoesterase
Structure domains: Purple Acid Phosphatase; chain A, domain 2
Calcineurin subunit B type 1
Molecule details ›
Chains: B, D
Length: 155 amino acids
Theoretical weight: 17.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: EF-hand domain pair
Structure domains: EF-hand
Length: 155 amino acids
Theoretical weight: 17.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P63098 (Residues: 16-170; Coverage: 91%)
Sequence domains: EF-hand domain pair
Structure domains: EF-hand
